The Reverend Libby Lane, 48, will be ordained as the new Bishop of Stockport, in what she says will be a “profound and remarkable moment”.
It comes after the general synod – the Church’s law-making body – voted to support the plans in July and formally adopted legislation in November.
The issue has continued to prompt divisions between some Anglicans.
profound and remarkable moment
Mrs Lane – who has been vicar of St Peter’s Hale and St Elizabeth’s Ashley, in Greater Manchester, since April 2007 – is expected to be consecrated in front of more than 1,500 people.
The two-hour service will be led by the Archbishop of York, Dr John Sentamu, during which he and other bishops will lay their hands on Mrs Lane and pray.
Mrs Lane, who was schooled in Manchester and at Oxford University, before training for ministry at Cranmer Hall in Durham, said more than 100 bishops were travelling to York for the service.